Neurobiology of Disease Aneuploidy and DNA Replication in the Normal Human Brain and Alzheimer’s Disease
نویسندگان
چکیده
Birgit Mosch,1,4 Markus Morawski,1,3 Anja Mittag,2 Dominik Lenz,2 Attila Tarnok,2 and Thomas Arendt1 1Paul Flechsig Institute of Brain Research, Department of Neuroanatomy, 2Department of Pediatric Cardiology, Cardiac Center Leipzig, and 3Interdisciplinary Center of Clinical Research, Faculty of Medicine, University of Leipzig, D-04109 Leipzig, Germany, and 4Institute of Radiopharmacy, Department of Radiopharmaceutical Biology, Research Center Dresden-Rossendorf, D-01328 Dresden, Germany
منابع مشابه
Alterations in adult hippocampal neurogenesis, aberrant protein s-nitrosylation, and associated spatial memory loss in streptozotocin-induced diabetes mellitus type 2 mice
Objective(s): Epidemiological and biochemical studies conducted over the past two decades have established a strong link between type 2 diabetes mellitus (T2DM) and Alzheimer’s disease (AD). However, the exact mechanisms through which aberrations in insulin signaling associated with T2DM contribute to cognitive decline are not yet known. Materials and Methods: In an effort to explore possible m...
متن کاملThe DNA Replication Stress Hypothesis of Alzheimer's Disease
A well-recognized theory of Alzheimer's disease (AD) pathogenesis suggests ectopic cell cycle events to mediate neurodegeneration. Vulnerable neurons of the AD brain exhibit biomarkers of cell cycle progression and DNA replication suggesting a reentry into the cell cycle. Chromosome reduplication without proper cell cycle completion and mitotic division probably causes neuronal cell dysfunction...
متن کاملExtracellular Vesicles as Neprilysin Delivery Syemory Improvement of Alzheimer’s Disease
Alzheimer’s disease (AD) is a neurodegenerative brain disorder which has no effective treatment yet due to the blood barrier in the brain that limits the drugs with the potential of disease improvement. Extracellular vesicles (EVs) are biocompatible nanoparticles with a lipid membrane. These vesicles are secreted from various cells such as mesenchymal stem cells (MSCs) and can pass through biol...
متن کاملExtracellular Vesicles as Neprilysin Delivery Syemory Improvement of Alzheimer’s Disease
Alzheimer’s disease (AD) is a neurodegenerative brain disorder which has no effective treatment yet due to the blood barrier in the brain that limits the drugs with the potential of disease improvement. Extracellular vesicles (EVs) are biocompatible nanoparticles with a lipid membrane. These vesicles are secreted from various cells such as mesenchymal stem cells (MSCs) and can pass through biol...
متن کاملBiophysical properties of single potassium channel in the brain mitochondrial inner membrane of male rat with Alzheimer’s disease
Introduction: Alzheimer’s disease is a progressive neurodegenerative disorder, characterized by impairment of memory and changes in behavior and personality. Recent evidence suggests that mitochondrial channels play important roles in memory disorders. Accordingly, the biophysical properties of a single potassium channel were investigated in the brain mitochondrial inner membrane of rat with...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2007